Hair analysis in clinical and forensic toxicology /

Hair Analysis in Clinical and Forensic Toxicology is an essential reference for toxicologists working with, and researching, hair analysis. The text presents a review of the most up-to-date analytical methods in toxicological hair analysis, along with state-of-the-art developments in the areas of ha...

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Other Authors: Kintz, Pascal (Editor), Salomone, Alberto (Editor), Vincenti, Marco (Editor)
Format: eBook
Language:English
Published: London : Academic Press, [2015]
Subjects:
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520 |a Hair Analysis in Clinical and Forensic Toxicology is an essential reference for toxicologists working with, and researching, hair analysis. The text presents a review of the most up-to-date analytical methods in toxicological hair analysis, along with state-of-the-art developments in the areas of hair physiology, sampling, and pre-treatments, as well as discussions of fundamental issues, applications, and results interpretation. Topics addressed include the diagnosis of chronic excessive alcohol drinking by means of ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEE), the early detection of new psychoactive substances, including designer drugs, the development of novel approaches to screening tests based on mass spectrometry, and the detection of prenatal exposure to psychoactive substances from the analysis of newborn hair. 
505 0 |a Front Cover; Hair Analysis in Clinical and Forensic Toxicology; Copyright Page; Contents; Foreword; List of Contributors; 1 Anatomy and Physiology of Hair, and Principles for its Collection; 1.1 Introduction; 1.2 Hair Anatomy and Physiology; 1.3 Classification of Hair Types; 1.4 Hair Growth Rates; 1.5 Hair Color; 1.6 Mechanisms of Drug Incorporation; 1.7 Incorporation from the Bloodstream, Sebum and Sweat; 1.8 Incorporation from External Contamination; 1.9 Dose-Response Relationship; 1.10 Melanin Binding; 1.11 Sample Collection Protocols; 1.12 Collection Procedure. 
505 8 |a 1.12.1 Workplace Drug Testing1.12.2 Drug-Facilitated Crime; 1.12.3 Postmortem Investigations; 1.13 Discussion; 1.14 Conclusion; References; 2 Hair Sample Preparation, Extraction, and Screening Procedures for Drugs of Abuse and Pharmaceuticals; 2.1 Introduction; 2.2 Sample Preparation; 2.2.1 Segmentation; 2.2.2 Washing; 2.2.3 Obtaining a Representative Sample Aliquot; 2.3 Analyte Extraction; 2.3.1 Hydrolysis of the Hair Matrix; 2.3.2 Solvent Incubation; 2.4 Screening Strategies; 2.4.1 Immunoassays; 2.4.2 Chromatographic Procedures; 2.5 Concluding Remarks; References. 
505 8 |a 3 External Contamination: Still a Debate?3.1 Introduction; 3.1.1 Incorporation from the Bloodstream; 3.1.2 Incorporation from Sweat and Other Secretions; 3.1.3 Incorporation from External Contamination; 3.2 External Contamination: Commonly Encountered Drugs; 3.2.1 Smoke and Passive Inhalation; 3.2.2 Surface/Environmental Contamination: Poor Housekeeping; 3.3 Alcohol: FAEE and EtG; 3.4 Concluding Remarks; References; 4 Alcohol Biomarkers in Hair; 4.1 Introduction; 4.2 Alcohol Amount, Drinking Pattern, and Minor Metabolites of Ethanol in Hair; 4.3 Ethyl Glucuronide. 
505 8 |a 4.3.1 Formation and Incorporation of EtG in Hair4.3.2 Analytical Determination of EtG in Hair; 4.3.2.1 Sampling, Segmentation, and Storage; 4.3.2.2 External Decontamination; 4.3.2.3 Grinding or Cutting to Small Pieces; 4.3.2.4 Hair Extraction; 4.3.2.5 Clean-up; 4.3.2.6 GC-MS and GC-MS/MS Procedures; 4.3.2.7 LC-MS/MS Procedures; 4.3.2.8 Validation and Quality Assurance; 4.3.3 Alcohol Consumption and EtG Concentrations in Hair; 4.3.3.1 Animal Experiments; 4.3.3.2 Meta-analysis of EtG Concentration in Human Hair; 4.3.3.3 Basic EtG Levels in Hair of Abstainers. 
505 8 |a 4.3.3.4 EtG in Hair after Single Excessive Drinking4.3.3.5 Prospective Studies; 4.3.3.6 EtG in Hair and Retrospectively Self-Reported Drinking Data; 4.3.3.7 Effect of Decreased Kidney Function; 4.3.4 Cutoff Values, Sensitivity, and Specificity; 4.3.5 EtG in Nonhead Hair; 4.3.5.1 General Differences as Compared to Scalp Hair; 4.3.5.2 EtG in Pubic Hair; 4.3.5.3 EtG in Axillary Hair; 4.3.5.4 EtG in Chest, Arm, and Leg Hair; 4.3.6 Effect of Hair Color, Hair Care, and Cosmetic Treatment; 4.3.7 Effect of Other Parameters and Habits on EtG in Hair; 4.4 Fatty Acid Ethyl Esters. 
650 0 |a Hair  |x Analysis. 
650 0 |a Forensic toxicology. 
650 0 |a Drug testing. 
650 7 |a Drug testing.  |2 fast  |0 (OCoLC)fst00898710 
650 7 |a Forensic toxicology.  |2 fast  |0 (OCoLC)fst00932027 
650 7 |a Hair  |x Analysis.  |2 fast  |0 (OCoLC)fst00950360 
700 1 |a Kintz, Pascal,  |e editor. 
700 1 |a Salomone, Alberto,  |e editor. 
700 1 |a Vincenti, Marco,  |e editor. 
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