Quorum sensing : molecular mechanism and biotechnological application /

Quorum sensing (QS) is a process of bacterial cooperative behaviour that has an effect on gene regulation. This cell-to-cell communication system involves the production of signalling molecules according to cell density and growth stage. Virulence, the ability to infest a habitat and cause disease,...

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Bibliographic Details
Other Authors: Tommonaro, Giuseppina (Editor)
Format: Electronic eBook
Language:English
Published: [Place of publication not identified] : Academic Press, 2019.
Edition:First edition.
Subjects:
Online Access:CONNECT

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504 |a Includes bibliographical references and index. 
588 0 |a Online resource; title from PDF title page (EBSCO, viewed April 11, 2019). 
505 0 |a Front Cover; Quorum Sensing: Molecular Mechanism and Biotechnological Application; Copyright; Dedication; Contents; Contributors; Preface; Part 1: General: Chemistry and Microbiology; Chapter 1: The Chemical Language of Gram-Negative Bacteria; 1. Introduction; 2. Quorum Sensing System Architectures in Gram-Negative Bacteria; 2.1. AHL-Based Quorum Sensing; 2.2. AI-2 Based Quorum Sensing; 2.3. QS Systems Using Other Autoinducers; 3. Chemistry of Autoinducers; 3.1. N-Acyl Homoserine Lactones; 3.2. Cyclic Furanone Compounds; 3.3. Others; 3.4. Quorum Sensing in Marine Environments 
505 8 |a 4. Quorum Quenching Molecules4.1. A Case Study of Inhibitors of AHL Receptors: LasR Antagonists; 4.2. Enzymatic Inhibition of QS; 4.2.1. Enzymatic degradation and inactivation of AHLs; 4.2.2. Enzymatic degradation and inactivation of non-AHLs quorum sensing signals; 4.2.3. Biosynthesis inhibition of AHLs molecules; 4.2.4. Biosynthesis inhibition of AI-2; 5. Conclusion; Glossary; Abbreviations; References; Chapter 2: Analytical Approaches for the Identification of Quorum Sensing Molecules; 1. Introduction; 2. Sample Preparation; 2.1. Liquid-Liquid Extraction (LLE) 
505 8 |a 2.2. Solid Phase Extraction (SPE)3. Detection, Identification, and Quantification of QS Molecules; 3.1. Analytical Approaches for AHL Detection; 3.1.1. Biosensors; 3.1.2. Radiolabeled assays; 3.1.3. Colorimetric assays; 3.2. Analytical Approaches for AHL Identification and Quantification; 3.2.1. Gas chromatography-mass spectrometry (GC-MS); 3.2.2. Liquid chromatography-mass spectrometry (LC-MS); 3.2.3. Capillary electrophoresis-mass spectrometry (CE-MS); 3.2.4. Matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS); 3.2.5. Nuclear magnetic resonance spectroscopy 
505 8 |a 3.3. Analytical Approaches for Identification and Quantification of Other QS Molecules4. Concluding Remarks; Glossary; Abbreviations; References; Chapter 3: Quorum Sensing in Marine Biofilms and Environments; 1. Introduction; 2. The Discovery of and Growing Interest in Quorum Sensing in Marine Environments; 2.1. 1970s: Quorum Sensing was Discovered in the Marine Environment-The Vibrio-squid Model; 2.2. 1990-2010s: A Growing Interest in the Study of Quorum Sensing in Marine Environments 
505 8 |a 3. Overview of Prokaryotic Diversity and Compounds Involved in Quorum Sensing in Marine Environments and Biofilms3.1. Experimental Approaches to Characterize AIs in the Marine Environment; 3.2. AHLs, or Autoinducer-1 (AI-1); 3.3. Autoinducer-2 (AI-2); 3.4. Other AIs; 3.5. Diffusion of AIs in the Marine Environment; 3.6. V. harveyi (and the Harveyi clade), a Model for the Study of Quorum Sensing in Marine Bacteria; 4. Surface Biofilms and Holobionts: The Diversity of Microbial Habitats Enabling Quorum Sensing in the Marine Environment 
520 |a Quorum sensing (QS) is a process of bacterial cooperative behaviour that has an effect on gene regulation. This cell-to-cell communication system involves the production of signalling molecules according to cell density and growth stage. Virulence, the ability to infest a habitat and cause disease, is also governed by such communication signals. Quorum Sensing: Molecular mechanism and biotechnological application collects, describes and summarizes the most interesting results obtained from experts working on QS mechanisms. It contributes to the understanding of the molecular basis that regulates this mechanism, and describes new findings in fields of application. This volume describes the QS mechanism from its molecular basis to medical applications such as antibiotic therapy and involvement of QS in pathologies. This reference also analyzes its potential use in biotechnological applications such as food packaging, drug delivery, and marine biofilm. The broad scope of this title will be of significant use to researchers across several fields with interest in QS, including to microbiologists, chemists, biochemists and ecologists. 
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