Fed-batch cultures : principles and applications of semi-batch bioreactors /

Many, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background...

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Bibliographic Details
Main Authors: Lim, Henry C., 1935- (Author), Shin, Hwa Sung, 1974- (Author)
Format: eBook
Published: Cambridge : Cambridge University Press, 2013.
Series:Cambridge series in chemical engineering.
Online Access:CONNECT
Table of Contents:
  • Introduction to fed-batch bioreactors
  • Idealised reactors and fed-batch reactors
  • Maximisation of reaction rates and fed-batch operation
  • Phenomena that favour fed-batch operations
  • Classification and characteristics of fed-batch cultures
  • Models based on mass balance equations
  • Non-equation-based models
  • Experimental determination of specific rates
  • Optimization via Pontryagin's maximum principle
  • Computational techniques
  • Optimization of single and multiple isothermal reactions
  • Optimization of fed-batch cultures for cell mass production
  • Optimization of fed-batch cultures for metabolites
  • Simple, intuitive adaptive optimization
  • Measurements, estimation and control
  • Feasibility assessment and implementable feed rates.