Amphioxus immunity : tracing the origins of human immunity /

Amphioxus immunity : tracing the origins of human immunity /

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Bibliographic Details
Other Authors: Xu, Anlong (Editor)
Format: Electronic eBook
Language:English
Published: Amsterdam : Elsevier Ltd., [2016]
Subjects:
Amphioxus > Physiology.
Immune system.
Marine invertebrates > Physiology.
Immunity.
Online Access:CONNECT
Table of Contents:
  • Cover; Title Page; Copyright Page; Dedication; Contents; List of contributors; About the Author; Foreword; Preface; Chapter 1
  • Amphioxus as a Model for Understanding the Evolution of Vertebrates; 1.1
  • Brief introduction of amphioxus; 1.2
  • Biology of amphioxus; 1.2.1
  • Reproduction and embryogenesis of amphioxus; 1.2.2
  • Anatomy of amphioxus; 1.3
  • The story of amphioxus and early research studies in China; References; Chapter 2
  • Basic Knowledge of Immunology; 2.1
  • Immune organs; 2.1.1
  • Primary lymphoid organs; 2.1.1.1
  • Bone marrow; 2.1.1.2
  • Thymus; 2.1.2
  • Secondary lymphoid organs
  • 2.1.2.1
  • Lymph nodes2.1.2.2
  • Spleen; 2.1.2.3
  • Mucosa-associated lymphoid tissue; 2.2
  • Immune cells; 2.2.1
  • Lymphoid cells; 2.2.1.1
  • B cells; 2.2.1.2
  • T cells; 2.2.1.3
  • NK cells; 2.2.2
  • Innate immunity-associated cells; 2.2.2.1
  • Neutrophils; 2.2.2.2
  • Macrophages; 2.2.2.3
  • Dendritic cells; 2.3
  • Innate immunity; 2.3.1
  • Toll-like receptors involved in the signaling pathway; 2.3.2
  • NOD-like receptors and their functions; 2.3.3
  • RIG-like receptors; 2.3.4
  • C-type lectins; 2.3.5
  • The scavenger receptors; 2.3.6
  • Inflammation; 2.4
  • Adaptive immunity; 2.4.1
  • Specificity
  • 2.4.2
  • Diversity2.4.3
  • Immunological memory; 2.4.4
  • Self-nonself recognition; 2.5
  • Complement system; 2.5.1
  • Complement pathways; 2.5.1.1
  • Classical pathway; 2.5.1.2
  • Lectin pathway; 2.5.1.3
  • Alternative pathway; 2.5.2
  • Complement in host defense; References; Chapter 3
  • Immune Organs and Cells of Amphioxus; 3.1
  • Introduction; 3.2
  • Organs of the amphioxus immune system; 3.2.1
  • Amphioxus gill slits: the first immune defense line; 3.2.2
  • Amphioxus intestine: not just a digestive organ but also an immune organ; 3.3
  • Cells of the amphioxus immune system; 3.3.1
  • Phagocytes
  • 3.3.2
  • Lymphocyte-like cellsReferences; Chapter 4
  • Genomic and Transcriptomic View of Amphioxus Immunity; 4.1
  • Introduction; 4.2
  • Trace evidence of adaptive immunity; 4.2.1
  • TCRs, Igs, VLRs, and the origins of RAG; 4.2.2
  • MHC and genes involved in antigen presentation; 4.3
  • Extraordinary gene expansion in amphioxus innate immunity; 4.3.1
  • The TLR system; 4.3.2
  • The NLR system; 4.3.3
  • LRRIG proteins; 4.3.4
  • Other LRR-containing genes; 4.3.5
  • C-type lectins; 4.3.6
  • Scavenger receptors; 4.3.7
  • RIG-I-like helicases; 4.3.8
  • Complement-related receptors; 4.3.9
  • The TNF system
  • 4.3.10
  • Expansion and reshuffling of the death-fold domains4.3.11
  • Expansion of TIR adaptors, TRAFs, and initiator caspases; 4.3.12
  • Cytokines, kinases, and transcription factors; 4.4
  • Regulation of the amphioxus immune system; 4.4.1
  • Differential regulatory patterns between expanded gene families; 4.4.2
  • The regulation during bacterial infection; 4.4.3
  • The regulation of the terminal signaling network; 4.4.4
  • Differential expression patterns observed within TNF and IL-1R systems; 4.4.5
  • Major pathways in a complex signaling network; 4.4.6
  • A functional prototypic complement system
  • 4.4.7
  • The prototype of the oxidative burst-like system

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