Biological DNA sensor : the impact of nucleic acids on diseases and vaccinology /
Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific s...
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| Other Authors: | , |
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
London :
Elsevier Science,
©2014.
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| Subjects: | |
| Online Access: | CONNECT |
Table of Contents:
- Autophagy Functions as a Host Defense System Against Invading MycobacteriaSTING Mediates Autophagy-Dependent Elimination of Invading Mycobacteria; Part III. Autophagy and AIM2-Dependent Inflammatory Responses; Inflammasomes Mediate Inflammatory Innate Immune Responses; Autophagy-Deficiency Enhances Production of Proinflammatory Cytokine IL-1[beta]; Autophagy Limits dsDNA-Induced Activation of AIM2-Inflammasome; Conclusion; References; B: dsDNA and Its Part in Modulating Human Diseases; 5 Host DNA Induced Inflammation and Autoimmune Diseases; Introduction.
- Front Cover; Biological DNA Sensor; Copyright Page; Contents; List of Contributors; Preface; A: The Discovery of dsDNA Immunogenicity and the Definition of DNA Sensing Pathways; 1 Route to Discovering the Immunogenic Properties of DNA from TLR9 to Cytosolic DNA Sensors; Introduction; The Importance of the Innate Immune System; PAMPS and DAMPs; Pathogen Derived Nucleic Acids are Potent Activators of the Innate Immune System; Endosomal-Membrane Bound DNA Sensor
- TLR9; Toll-Like Receptors in Innate Immunity; TLR9 and CpG; Cytosolic DNA Sensors.
- Signs that TLR9 may not be the only DNA Intracellular SensorDsDNA Utilizes the TBK1-IRF3 Signaling Pathway; Identified Cytosolic DNA Sensors; Z-DNA Binding Protein-1 (ZBP-1); ZBP-1 Died or Dies Hard; Leucine-Rich Repeat (in Flightless I) Interacting Protein-1 (LRRFIP1); DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 41 (DDX41); RNA Polymerase III; PYHIN Family: AIM2 and IFI16; AIM2; AIM2 Regulation by p202; IFI16; DHX36 and DHX9; Ku70; HMGB Proteins; Histone H2B; MRE11; cGAMP as Second Messenger of the DNA Sensing and cGAS as a Cytosolic DNA Sensor; Conclusion; Acknowledgment; References.
- 2 The PYHIN Family of Molecules and their Functions Sensing dsDNAIntroduction; Members of the Pyhin Family; Structural Basis of DNA Recognition by PYHIN Proteins; Microbial DNA Sensing and Signaling by PYHIN Proteins; AIM2; IFI16; P204; p202 (IFI202) and other PYHIN Proteins; Transcriptional Regulation by PYHIN Proteins; Role of PYHIN Proteins in the Development of Autoimmunity; Regulation of PYHIN Proteins; Conclusions; References; 3 Cytosolic DNA-Sensing and the STING Pathway; Introduction; The Toll-Like Pathway: TLR9 and CpG DNA; The STING Pathway and Intracellular DNA Signaling.
- STING and Inflammatory DiseaseOther Sensors of Intracellular DNA; Conclusion; References; 4 Regulation of Intracellular dsDNA-Induced Innate Immune Responses by Autophagy-Related Proteins; Part I. Autophagy-Related Proteins and STING-Dependent IFN Responses; STING Mediates dsDNA-Induced Expression of Type I IFNs; Autophagy-Related Protein Regulates Membrane Trafficking and Induces Autophagosome Formation; Autophagy-Related Proteins Regulate STING-Mediated Expression of Type I IFNs; Part II. Autophagy and STING-Dependent Bactericidal Responses.
