Handbook of epigenetics : the new molecular and medical genetics /
Epigenetics is considered by many to be the "new genetics" because the realization that many biological phenomena are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes that have opened up new paths for discovery. The biological processe...
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| Format: | Electronic eBook |
| Language: | English |
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London :
Academic,
2010.
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| Online Access: | CONNECT |
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| 100 | 1 | |a Tollefsbol, Trygve O. | |
| 245 | 1 | 0 | |a Handbook of epigenetics : |b the new molecular and medical genetics / |c Trygve Tollefsbol. |
| 260 | |a London : |b Academic, |c 2010. | ||
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| 520 | |a Epigenetics is considered by many to be the "new genetics" because the realization that many biological phenomena are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes that have opened up new paths for discovery. The biological processes impacted by epigenetics range from tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation to genomic imprinting and aging. The effects of epigenetics are vast and encompass lower organisms as well as humans. Aberrations of epigenetics influence many diseases involving but not limited to cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases. Clinical intervention is already in place for some of these disorders and many novel epigenetic therapies are on the horizon. | ||
| 505 | 0 | |a 1. Epigenetics: The New Science of Genetics -- SECTION I: Molecular Mechanisms of Epigenetics -- 2. Mechanisms of DNA Methylation, Methy-CpG Recognition, and Demethylation in Mammals -- 3. Mechanisms of Histone Modifications -- SECTION II: Additional Epigenetic Processes -- 4. The Epigenetics of Non-coding RNA -- 5. Prions and Prion-like Phenomena in Epigenetic Inheritance -- 6. Chromosomal Position Effects and Gene Variegation: Impact in Pathologies -- 7. Polycomb Mechanisms and Epigenetic Control of Gene Activity -- SECTION III: Epigenetic Technology -- 8. Analysis of Gene-specific DNA Methylation -- 9. Methods for Assessing Genome-wide DNA Methylation -- 10. Methylation of Lysine-9 of Histone H3: Role in Heterochromatin Modulation and Tumorigenesis -- 11. Chromatin Modifications Distinguish Genomic Features and Physical Organization of the Nucleus -- 12. Assessing Epigenetic Information -- SECTION IV: Model Organisms of Epigenetics -- 13. Epigenetics of Eukaryotic Microbes -- 14. Drosophila Epigenetics -- 15. Mouse Models of Epigenetic Inheritance -- 16. Epigenetic Regulatory Mechanisms in Plants -- SECTION V: Metabolism and Epigenetics -- 17. Metabolic Regulation of DNA Methylation in Mammals -- 18. Dietary and Metabolic Compounds Affecting Chromatin Dynamics/Remodeling -- SECTION VI: Functions of Epigenetics -- 19. Epigenetics, Stem Cells and Cellular Differentiation -- 20. Epigenetic Basis of Skeletal Muscle Regeneration -- 21. Epigenetics of X Chromosome Inactivation -- 22. Genomic Imprinting -- 23. Epigenetics of Memory Processes -- 24. Transgenerational Epigenetics -- 25. Aging Epigenetics -- SECTION VII: Evolutionary Epigenetics -- 26. Epigenetics in Adaptive Evolution and Development -- SECTION VIII: Epigenetic Epidemiology -- 27. The Effects of Diet on Epigenetic Processes -- 28. Environmental Agents and Epigenetics -- 29. Impact of Microbial Infections on the Human Epigenome and Carcinogenesis -- 30. DNA Methylation Profiles in the 5'-Upstream Region of the Human FMR1 Promoter and in an Adenovirus Transgenome -- 31. Population Pharmacoepigenomics -- SECTION IX: Epigenetics and Human Disease -- 32. Cancer Epigenetics -- 33. The Role of Epigenetics in Immune Disorders -- 34. Epigenetics of Brain Disorders -- 35. Complex Metabolic Syndromes and Epigenetics -- 36. Imprinting Disorders in Humans -- SECTION X: Epigenetic Therapy -- 37. Clinical Applications of Histone Deacetylase Inhibitors. | |
| 588 | 0 | |a Print version record. | |
| 504 | |a Includes bibliographical references and index. | ||
| 500 | |a ScienceDirect eBook - Biochemistry, Genetics and Molecular Biology 2010 |5 TMurS | ||
| 650 | 0 | |a Epigenesis. | |
| 650 | 0 | |a Genetic regulation. | |
| 655 | a | |a Wörterbuch. | |
| 730 | 0 | |a WORLDSHARE SUB RECORDS | |
| 758 | |i has work: |a Handbook of epigenetics (Text) |1 https://id.oclc.org/worldcat/entity/E39PCFWCymmVPyRM8d6bMhDJfy |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
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