DNA repair in cancer therapy : molecular targets and clinical applications /
Cancer therapeutics include an ever-increasing array of tools at the disposal of clinicians in their treatment of this disease. However, cancer is a tough opponent in this battle, and current treatments, which typically include radiotherapy, chemotherapy and surgery, are not often enough to rid the...
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
Amsterdam ; Boston :
Academic Press,
2012.
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| Subjects: | |
| Online Access: | CONNECT |
Table of Contents:
- Introduction and Overview of Current Targets: Bench to Clinic / Mark R. Kelley
- 2. MGMT a Critical DNA Repair Gene Target for Chemotherapy Resistance / Stanton L. Gerson and Lili Liu
- 3. Blockade of Base Excision Repair: Inhibitionof Small Lesions Results in Big Consequences to Cancer Cells / Melissa Fishel and Carlo Vascotto
- 4. PARP Inhibitors
- Scientific Rationale and Clinical Development for Cancer / Ruth Plummer, Nicola J. Curtin and Yvette Drew
- 5. Inhibiting Selective DNA Polymerases for Therapeutic Intervention / Anthony J. Berdis
- 6. Targeting the Nucleotide Excision Repair Pathway for Therapeutic Applications / John Turchi and Stephan M. Patrick
- 7. Homologous Recombination and ATM/ATR Targets / Henning Willers, Lee Zou and Heike N. Pfaffle
- 8. DNA Double Strand Break Repair by Nonhomologous End Joining and its Clinical Relevance / Michael Weinfeld and Susan Lees-Miller
- 9. Defective MMR-c-Abl-p73-GADD45alpha Expression in Cancer Chemoresistance / David Boothman and Long Shan Li
- 10. DNA Repair Signaling Targets / Susan Ashwell
- 11. Redox Regulation of DNA Repair and Therapeutic / Millie M. Georgiadis
- 12. Personalized Cancer Medicine: DNA Repair Alterations is a Promising Predictive Marker in Cancer / Srinivasan Madhusudan
- 13. The Role of DNA Damage and Repair in Neurotoxicity Caused by Cancer Therapies / Michael R. Vasko
- 14. Future Directions / Mark R. Kelley.
