Signal transduction /

Up-to-date, inclusive coverage of targeting transduction pathways for research and medical intervention * In-depth coverage of nuclear receptors, including steps in isolation of steriod hormones and the discovery of intracellular hormone receptors; Tyrosine protein kinases and adaptive immunity; and...

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Bibliographic Details
Main Author: Gomperts, B. D.
Other Authors: Tatham, Peter E. R. (Life scientist), Kramer, Ijsbrand M.
Format: Electronic eBook
Language:English
Published: Amsterdam ; Boston : Elsevier/Academic Press, ©2009.
Edition:2nd ed.
Subjects:
Online Access:CONNECT
Table of Contents:
  • Prologue: Signal Transduction, origins and ancestors
  • First messengers
  • Receptors
  • GTP-binding proteins and signal transduction
  • Effector enzymes coupled to GTP binding proteins: adenylyl cyclase and phospholipase C
  • The regulation of visual transduction and olfaction
  • Intracellular calcium
  • Calcium effectors
  • Phosphorylation and dephosphorylation: protein kinases A and C
  • Nuclear receptors
  • Growth Factors: Setting the framework
  • Signalling pathways operated by receptor protein tyrosine kinases
  • Signal transduction to and from adhesion molecules
  • Adhesion molecules in the regulation of cell differentiation: Mainly about Wnt
  • Activation of the innate immune system: the Toll-like receptor 4 and Signalling through Ubiquitylation
  • Traffic of white blood cells
  • Tyrosine protein kinases and adaptive immunity : TCR, BCR, soluble tyrosine kinases and NFAT
  • Phosphoinositide 3-kinases, protein kinase B and signalling through the insulin receptor
  • Protein Kinase C revisited
  • Signalling through receptor serine/threonine kinases
  • Protein dephosphorylation and protein phosphorylation
  • Notch
  • Targeting transduction pathways for research and medical intervention
  • Protein domains and signal transduction.