Bioreactors : design, operation and novel applications /
In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products...
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| Other Authors: | |
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| Format: | eBook |
| Language: | English |
| Published: |
Weinheim :
Wiley-VCH Verlag GmbH & Co.,
[2016]
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| Subjects: | |
| Online Access: | CONNECT CONNECT |
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| 245 | 0 | 0 | |a Bioreactors : |b design, operation and novel applications / |c edited by Carl-Fredrik Mandenius. |
| 264 | 1 | |a Weinheim : |b Wiley-VCH Verlag GmbH & Co., |c [2016] | |
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| 504 | |a Includes bibliographical references and index. | ||
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| 520 | 8 | |a In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. | |
| 505 | 0 | |a Title Page -- Copyright -- Table of Contents -- Preface -- List of Contributors -- Chapter 1: Challenges for Bioreactor Design and Operation -- 1.1 Introduction -- 1.2 Biotechnology Milestones with Implications on Bioreactor Design -- 1.3 General Features of Bioreactor Design -- 1.4 Recent Trends in Designing and Operating Bioreactors -- 1.5 The Systems Biology Approach -- 1.6 Using Conceptual Design Methodology -- 1.7 An Outlook on Challenges for Bioreactor Design and Operation -- References -- Chapter 2: Design and Operation of Microbioreactor Systems for Screening and Process Development. | |
| 505 | 8 | |a 2.1 Introduction -- 2.2 Key Engineering Parameters and Properties in Microbioreactor Design and Operation -- 2.3 Design of Novel Stirred and Bubble Aerated Microbioreactors -- 2.4 Robotics for Microbioreactors -- 2.5 Fed-Batch and Continuous Operation of Microbioreactors -- 2.6 Monitoring and Control of Microbioreactors -- 2.7 Conclusion -- References -- Chapter 3: Bioreactors on a Chip -- 3.1 Introduction -- 3.2 Advantages of Microsystems -- 3.3 Scaling Down the Bioreactor to the Microfluidic Format -- 3.4 Microfabrication Methods for Bioreactors-On-A-Chip -- 3.5 Fabrication Materials. | |
| 505 | 8 | |a 3.6 Integrated Sensors for Key Bioreactor Parameters -- 3.7 Model Organisms Applied to BRoCs -- 3.8 Applications of Microfluidic Bioreactor Chip -- 3.9 Scale Up -- 3.10 Conclusion -- References -- Chapter 4: Scalable Manufacture for Cell Therapy Needs -- 4.1 Introduction -- 4.2 Requirements for Cell Therapy -- 4.3 Stem Cell Types and Products -- 4.4 Paradigms in Cell Therapy Manufacture -- 4.5 Cell Therapy Manufacturing Platforms -- 4.6 Microcarriers and Stirred-Tank Bioreactors -- 4.7 Future Trends for Microcarrier Culture -- 4.8 Preservation of Cell Therapy Products -- 4.9 Conclusions. | |
| 505 | 8 | |a 6.2 Culture Technologies for Pluripotent Stem Cell Expansion -- 6.3 3D Suspension Culture -- 6.4 Autologous Versus Allogeneic Cell Therapies: Practical and Economic Considerations for hPSC Processing -- 6.5 Upscaling hPSC Cardiomyogenic Differentiation in Bioreactors -- 6.6 Conclusion -- References -- Chapter 7: Culturing Entrapped Stem Cells in Continuous Bioreactors -- 7.1 Introduction -- 7.2 Materials Used in Stem Cell Entrapment -- 7.3 Synthetic Materials -- 7.4 Natural Materials -- 7.5 Manufacturing and Regulatory Constraints -- 7.6 Mass Transfer in the Entrapment Material. | |
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