Cell culture engineering : recombinant protein production /

Offers a comprehensive overview of cell culture engineering, providing insight into cell engineering, systems biology approaches and processing technology In Cell Culture Engineering: Recombinant Protein Production, editors Gyun Min Lee and Helene Faustrup Kildegaard assemble top class authors to pr...

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Bibliographic Details
Other Authors: Lee, Gyun Min (Editor), Kildegaard, Helene Faustrap (Editor)
Format: eBook
Published: Weinheim, Germany : Wiley-VCH, [2020]
Series:Advanced biotechnology ; v. 9.
Online Access:CONNECT
Table of Contents:
  • 1. Platform Technology for Therapeutic Protein Production
  • 2. Cell Line Development for Therapeutic Protein Production
  • 3. Transient Gene Expression-Based Protein Production in Recombinant Mammalian Cells
  • 4. Enhancing Product and Bioprocess Attributes Using Genome-Scale Models of CHO Metabolism
  • 5. Genome Variation, the Epigenome and Cellular Phenotypes
  • 6. Adaption of Generic Metabolic Models to Specific Cell Lines for Improved Modeling of Biopharmaceutical Production and Prediction of Processes
  • 7. Toward Integrated Multi-omics Analysis for Improving CHO Cell Bioprocessing
  • 8. CRISPR Toolbox for Mammalian Cell Engineering
  • 9. CHO Cell Engineering for Improved Process Performance and Product Quality
  • 10. Metabolite Profiling of Mammalian Cells
  • 11. Current Considerations and Future Advances in Chemically Defined Medium Development for the Production of Protein Therapeutics in CHO Cells
  • 12. Host Cell Proteins During Biomanufacturing
  • 13. Mammalian Fed-batch Cell Culture for Biopharmaceuticals
  • 14. Continuous Biomanufacturing
  • 15. Process Analytical Technology and Quality by Design for Animal Cell Culture
  • 16. Development and Qualification of a Cell Culture Scale-Down Mode
  • References
  • Index.