Chemogenomics in drug discovery : a medicinal chemistry perspective /
Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. The first reference devoted to the topic, this up-to-date resource covers all stages of the early drug discovery process, from target selection to c...
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| Other Authors: | , |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Weinheim :
Wiley-VCH,
©2004.
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| Series: | Methods and principles in medicinal chemistry ;
v. 22. |
| Subjects: | |
| Online Access: | CONNECT |
Table of Contents:
- Target family-directed masterkeyes in chemogenomics / Gehard Müller
- Drug discovery from side effects / Hugo Kubinyi
- The value of chemical genetics in drug discovery / Keith Russell and William F. Michne
- Structural aspects of binding site similarity: a 3D upgrade for chemogenomics / Andreas Bergner and Judith Günther
- The contribution of molecular informatics to chemogenomics: knowledge-based discovery of biological targets and chemical lead compounds / Edgar Jacoby, Ansgar Schuffenhauer, and Pierre Acklin
- Chemical kinomics / Bert M. Klebl, Henrik Daub, and György Kéri
- Structural aspects of kinases and their inhibitors / Rogier Buijsman
- A chemical genomics approach for ion channel modulators / Karl-Heinz Baringhaus and Gerhard Hessler
- Phosphodiesterase inhibitors: a chemogenomic view / Martin Hendrix and Christopher Kallus
- Proteochemometrics: a tool for modeling the molecular interaction space / Jarl E.S. Wikberg, Maris Lapinsch, and Peteris Prusis
- Some principles related to chemogenomics in compound library and template design for GPCRs / Thomas R. Webb
- Computational filters in lead generation: targeting drug-like chemotypes / Wolfgang Guba and Olivier Roche
- Navigation in chemical space: ligand-based design of focused compound libraries / Gisbert Schneider and Petra Schneider
- Natural product-derived compound libraries and protein structure similarity as guiding principles for the discovery of drug candidates / Marcus A. Koch and Herbert Waldmann
- Combinatorial chemistry in the age of chemical genomics / Reni Joseph and Prabhat Arya.
