Protein-ligand interactions from molecular recognition to drug design /
The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specifici...
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| Other Authors: | , |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Weinheim :
Wiley-VCH,
©2003.
|
| Series: | Methods and principles in medicinal chemistry ;
v. 19. |
| Subjects: | |
| Online Access: | CONNECT |
MARC
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| 245 | 0 | 0 | |a Protein-ligand interactions from molecular recognition to drug design / |c edited by H.-J. Böhm and G. Schneider. |
| 260 | |a Weinheim : |b Wiley-VCH, |c ©2003. | ||
| 300 | |a 1 online resource (xx, 242 pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
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| 490 | 1 | |a Methods and principles in medicinal chemistry ; |v v. 19 | |
| 500 | |a Wiley EBA |5 TMurS | ||
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a Protein-Ligand Interactions From Molecular Recognition to Drug Design; Contents; Preface; A Personal Foreword; List of Contributors; List of Abbreviations; Prologue; 1 Prediction of Non-bonded Interactions in Drug Design; 2 Introduction to Molecular Recognition Models; 3 Experimental Approaches to Determine the Thermodynamics of Protein-Ligand Interactions; 4 The Biophore Concept; 5 Receptor-Ligand Interaction; 6 Hydrogen Bonds in Protein-Ligand Complexes; 7 Principles of Enzyme-Inhibitor Design; 8 Tailoring Protein Scaffolds for Ligand Recognition. | |
| 520 | |a The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contribution. | ||
| 546 | |a English. | ||
| 650 | 0 | |a Proteins. | |
| 650 | 0 | |a Ligands. | |
| 650 | 0 | |a Ligand binding (Biochemistry) | |
| 650 | 0 | |a Carrier proteins. | |
| 650 | 0 | |a Drugs |x Design. | |
| 650 | 0 | |a Ligands (Biochemistry) | |
| 650 | 2 | |a Ligands | |
| 650 | 2 | |a Carrier Proteins | |
| 650 | 2 | |a Drug Design | |
| 650 | 2 | |a Models, Molecular | |
| 650 | 2 | |a Proteins | |
| 700 | 1 | |a Böhm, Hans-Joachim. | |
| 700 | 1 | |a Schneider, Gisbert, |d 1965- | |
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| 830 | 0 | |a Methods and principles in medicinal chemistry ; |v v. 19. | |
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