Therapeutic monoclonal antibodies : from bench to clinic /
The first therapeutic antibody, murine-derived Muromonab OKT3ʼ, was approved by the FDA in 1986 to treat acute organ rejection. Since then, monoclonal antibody therapeutics have played an increasing role in combating human diseases. To discover the state of the science and where this burgeoning fiel...
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| Other Authors: | |
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
Hoboken, N.J. :
John Wiley & Sons,
©2009.
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| Subjects: | |
| Online Access: | CONNECT |
MARC
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| 245 | 0 | 0 | |a Therapeutic monoclonal antibodies : |b from bench to clinic / |c edited by Zhiqiang An. |
| 260 | |a Hoboken, N.J. : |b John Wiley & Sons, |c ©2009. | ||
| 300 | |a 1 online resource (xv, 889 pages, 16 unnumbered pages of plates : : |b illustrations (some color.) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 500 | |a Wiley EBA |5 TMurS | ||
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Antibody basics -- Therapeutic monoclonal antibodies: past, present, and future -- Antibody molecular structure -- Glycosylation of therapeutic IgGs -- Antibody databases and tools: the IMGT experience -- Antibody sources -- Human antibodies from transgenic mice -- Rabbit hybridoma -- Human antibody repertoire libraries -- In vitro display technology -- Antibody phage display -- Yeast surface display -- Ribosomal display -- Bacterial display of antibodies -- Antibody selection from immunoglobulin libraries expressed in mammalian cells -- Antibody engineering -- Antibody engineering: humanization, affinity maturation, and selection techniques -- Modulation of serum protein homeostasis and transcytosis by the neonatal Fc receptor -- Engineering the antibody Fc region for optimal effector function -- Physiology and in vivo biology -- Antibody-complement interaction -- Bacteria immunoglobulin-binding proteins: biology and practical applications -- Immunogenicity screening using in silico methods: correlation between T-cell epitope content and clinical immunogenicity of monoclonal antibodies -- Monoclonal antibody pharmacokinetics and pharmacodynamics -- Biodistribution and imaging -- Antibodies and the blood-brain barrier -- Antibody characterization -- Determination of equilibrium dissociation constants -- Molecular and functional characterization of monoclonal antibodies -- Characterization of heterogeneity in monoclonal antibody products -- Antibody expression -- Antibody expression in mammalian cells -- Production of antibodies in Pichia pastoris -- Production of antibody Fab' fragments in E. coli -- Production of human therapeutic monoclonal antibodies in chicken eggs -- Production of antibodies in plants -- Therapeutic antibodies -- Formulation and delivery of monoclonal antibodies -- Therapeutic antibodies in clinical use and leading clinical conditions -- Follow-on protein products: what, where, when, how? -- Monomeric Fc fusion molecules -- Radioimmunotherapy: current status and future directions -- Antibody-drug conjugate therapy. | |
| 520 | |a The first therapeutic antibody, murine-derived Muromonab OKT3ʼ, was approved by the FDA in 1986 to treat acute organ rejection. Since then, monoclonal antibody therapeutics have played an increasing role in combating human diseases. To discover the state of the science and where this burgeoning field is heading, readers should turn to this 35-chapter work. It is the first book that draws together all the latest findings, tools, and practices that span the entire process of discovery, development, and clinical application of therapeutic monoclonal antibodies. | ||
| 520 | 8 | |a Therapeutic Monoclonal Antibodies reviews: | |
| 520 | 8 | |a Basic antibody biology and antibody sources. | |
| 520 | 8 | |a Physiology and in vivo biology. | |
| 520 | 8 | |a Antibody production and delivery. | |
| 520 | 8 | |a Therapeutic monoclonal antibodies in clinical use and in clinical trial. | |
| 520 | 8 | |a Chapters are written by one or more leading practitioners with hands-on experience in the area. The authors have provided not only theories but also methodologies that readers can use in their own laboratories. Moreover, experimental data is offered in most chapters to illustrate key principles. | |
| 520 | 8 | |a Therapeutic Monoclonal Antibodies is recommended for biotechnologists, immunologists, medicinal and pharmaceutical chemists, bioengineers, bioprocess technologists, biochemists, and students. It will help them advance their own basic and clinical research by taking advantage of the latest findings in the discovery, development, and clinical application of therapeutic monoclonal antibodies. | |
| 588 | |a Description based on print version record. | ||
| 650 | 0 | |a Monoclonal antibodies |x Therapeutic use. | |
| 650 | 1 | 2 | |a Antibodies, Monoclonal |x therapeutic use |
| 650 | 2 | 2 | |a Drug Discovery |
| 700 | 1 | |a An, Zhiqiang, |c Dr. | |
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