Multicomponent reactions : concepts and applications for design and synthesis /

Multicomponent reactions : concepts and applications for design and synthesis /

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Addressing a dynamic aspect of organic chemistry, this book describes synthetic strategies and applications for multicomponent reactions - including key routes for synthesizing complex molecules. - Illustrates the crucial role and the important utility of multicomponent reactions (MCRs) to organic s...

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Bibliographic Details
Other Authors: Herrera, Raquel P., 1977- (Editor), Marques-Lopez, Eugenia, 1978- (Editor)
Format: Electronic eBook
Language:English
Published: Hoboken, New Jersey : John Wiley & Sons, Inc., [2015]
Subjects:
Chemical reactions.
Catalysis.
Chemistry, Organic.
Catalysis
Chemistry, Organic
Online Access:CONNECT
Table of Contents:
  • Title Page
  • Copyright Page
  • Contents
  • List of Contributors
  • Preface
  • List of Abbreviations
  • Chapter 1 Introduction: Multi-component Strategies
  • General Introduction
  • 1.1 Basic Concepts
  • 1.1.1 Clarifying Terminology: One-Pot, Domino/Cascade, Tandem, and MCRs
  • 1.1.2 Using Rational Design to Discover New MCRs
  • 1.1.3 Discovering New MCRs with Automated Combinatorial Reaction Finding
  • 1.1.4 Computational and Analytical Tools to Study MCRs
  • 1.1.5 Diversity-Oriented Synthesis and Biology-Oriented Synthesis
  • 1.1.6 Optimization of MCRs
  • 1.2 Catalysis in MCRs and Various Synthetic Approaches1.2.1 Organocatalysis in MCRs
  • 1.2.2 Organometallic Catalysis in MCRs
  • 1.2.3 Biocatalysis in MCRs
  • 1.2.4 Combining Different Types of Catalysis
  • 1.2.5 Other Methods
  • 1.3 Green Chemistry
  • 1.3.1 Atom Economy
  • 1.3.2 Using Green Solvents
  • 1.3.3 Solventless MCRs
  • 1.3.4 Heterogeneous Catalysis in MCRs
  • 1.4 Importance and Evolution
  • References
  • Chapter 2 Organocatalytic Asymmetric Multicomponent Reactions
  • 2.1 Introduction
  • 2.2 Three-Component Mannich Reaction
  • 2.3 Cycloaddition Reaction2.4 Organocatalytic Multicomponent Domino Asymmetric Reactions
  • 2.4.1 Michael-Type Multicomponent Process: Cyclic Carbon Frameworks
  • 2.4.2 Miscellaneous Domino Reactions
  • 2.5 Development of Drug Intermediates
  • 2.6 Miscellaneous Reaction
  • 2.7 Conclusions
  • References
  • Chapter 3 Metal-Catalyzed Multicomponent Reactions
  • 3.1 Introduction
  • 3.2 Palladium-Catalyzed MCRs
  • 3.2.1 Palladium-Catalyzed Carbonylation Reactions
  • 3.2.2 Palladium-Catalyzed MCRs Involving Isocyanides
  • 3.2.3 Carbopalladation of Unsaturated Câ?€C Ï€-Components3.2.4 Amines as Building Blocks
  • 3.3 Nickel-Catalyzed MCRs
  • 3.3.1 Nickel-Catalyzed Cross-Trimerization of Alkynes
  • 3.3.2 Nickel-Catalyzed Ï€-Systems Couplings
  • 3.3.3 Ni-Catalyzed Reductive Conjugate Addition
  • 3.4 Group 11 Metal-Catalyzed MCRs
  • 3.4.1 Copper-Catalyzed Azide Alkyne Cycloaddition
  • 3.4.2 A3-Coupling
  • 3.4.3 Miscellaneous
  • 3.5 Rhodium-Catalyzed MCRs
  • 3.5.1 Rhodium-Catalyzed Mcrs via Onium Ylide Intermediates
  • 3.5.2 Rhodium-Catalyzed Three-Component Cross-Addition Reactions
  • 3.6 Group 8 Metal-Catalyzed MCRs3.6.1 Iron-Catalyzed MCRs
  • 3.6.2 Ruthenium-Catalyzed MCRs
  • 3.7 Conclusions
  • References
  • Chapter 4 Multicomponent Reactions with Organoboron Compounds
  • 4.1 Introduction
  • 4.2 Catalytic MCRs with Organoboron Compounds
  • 4.2.1 Cobalt-Catalyzed MCRs Containing Organoboron Compounds
  • 4.2.2 Palladium-Catalyzed MCRs Containing Organoboron Compounds
  • 4.3 Multicomponent Assembly of Organoboron Compounds: Efficient Approach to Supramolecular Chemistry
  • 4.4 Multicomponent Petasis-Borono Mannich Reaction

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