Integrated strategies for drug discovery using mass spectrometry /
New strategies and techniques for today's fast-paced discovery processToday, the pressure is on for high-throughput approaches to accelerate the generation, identification, and optimization of molecules with desirable drug properties. As traditional methods of analysis become antiquated, new an...
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| Other Authors: | |
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
Hoboken, N.J. :
Wiley-Interscience,
©2005.
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| Subjects: | |
| Online Access: | CONNECT |
MARC
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| 245 | 0 | 0 | |a Integrated strategies for drug discovery using mass spectrometry / |c [edited by] Mike S. Lee. |
| 260 | |a Hoboken, N.J. : |b Wiley-Interscience, |c ©2005. | ||
| 300 | |a 1 online resource (xvii, 550 pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
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| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Miniaturized formats for efficient liquid chromatography mass spectrometry-based proteomics and therapeutic development / Gary A. Valaskovic and Neil Kelleher -- Mass-spectrometry-based drug screening assays for early phases in drug discovery / Marshall M. Siegel -- ESI-FTICR as a high throughput drug discovery platform / Kristin A. Sannes-Lowery [and others] -- Mass spectrometry-based proteomic approaches for disease diagnosis and biomarker discovery / Thomas P. Conrads [and others] -- Metabonomic applications in toxicity screening and disease diagnosis / John P. Shockcor and Elaine Holmes -- The central role of mass spectrometry in natural products discovery / Jeffrey R. Gilbert [and others]. | |
| 505 | 0 | |a Application of mass spectrometry to compound library generation, analysis, and management / Xueheng Cheng and Jill Hochlowski -- A combinatorial process for drug discovery / David S. Wagner [and others] -- Application of technological advances in biotransformation studies / Carmen L. Fernández-Metzler, Raju Subramanian and Richard C. King -- Applications of mass spectrometry for the characterization of reactive metabolites of drugs in discovery / Jim Wang [and others] -- Advances in high throughput quantitative drug discovery bioanalysis / Bradley L. Ackermann, Michael J. Berna and Anthony T. Murphy. | |
| 505 | 0 | |a New strategies for the implementation and support of bioanalysis in a drug metabolism environment / Walter A. Korfmacher -- An integrated LC-MS strategy for preclinical candidate optimization / Jonathan L. Josephs and Mark Sanders -- New approaches for method development and purification in lead optimization / Yining Zhao and David J. Semin -- High throughput metabolic and physicochemical property analysis / Edward H. Kerns and Li Di -- Organ perfusion and mass spectrometry / C. Gerald Curtis [and others] -- Sample preparation for drug discovery bioanalysis / David A. Wells -- Automation / John D. Laycock and Thomas Hartmann. | |
| 588 | 0 | |a Print version record. | |
| 520 | |a New strategies and techniques for today's fast-paced discovery processToday, the pressure is on for high-throughput approaches to accelerate the generation, identification, and optimization of molecules with desirable drug properties. As traditional methods of analysis become antiquated, new analytical strategies and techniques are necessary to meet sample throughput requirements and manpower constraints. | ||
| 650 | 0 | |a Mass spectrometry. | |
| 650 | 0 | |a Drugs |x Analysis. | |
| 650 | 0 | |a High throughput screening (Drug development) | |
| 650 | 0 | |a Drugs |x Design. | |
| 650 | 0 | |a Pharmacokinetics. | |
| 650 | 1 | 2 | |a Drug Design |
| 650 | 1 | 2 | |a Pharmaceutical Preparations |x analysis |
| 650 | 2 | 2 | |a Chromatography, Liquid |x methods |
| 650 | 2 | 2 | |a Pharmacokinetics |
| 650 | 2 | 2 | |a Mass Spectrometry |x methods |
| 650 | 2 | |a Mass Spectrometry | |
| 700 | 1 | |a Lee, Mike S., |d 1960- | |
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